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water mist 13

water resources 13

drinking water 11

water 11

water quality 10

sustainable development 9

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Adsorption 6

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Design new ideas and engineering practice of high-pressure water-rich fault “outside block and insidestrenghthen grouting”

Zhang Minqing,Zhang Mei

Strategic Study of CAE 2009, Volume 11, Issue 12,   Pages 26-34

Abstract: was changed into "outside block and inside strengthen grouting" .advanced prospecting holes, and adopts normal grouting for weak water area and strengthened groutingfor strong water area, following the principle of "blocking cracks to reduce water quantity, strengtheningin strata, then grouting is adopted abiding by the principle of "appropriate drawing pace, blockingblocking water and strengthen.

Keywords： high-pressure water-rich fault     unevenness     blocking water and strengthen by grouting     outside blockand inside solid grouting     innovation    

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Synchronous grouting of large diameter slurry shield in water-rich sandy gravel stratum

Zhang Changqiang,Zhai Zhiguo,Chen Mingjuan,Jin Zhongxiang

Strategic Study of CAE 2010, Volume 12, Issue 12,   Pages 75-78

Abstract: the technical data which based on shield tunneling, comprehensively considering the information of water-richstratum deformation mechanism information, the empirical formula of the main parameters of synchronized grouting

Keywords： sandy gravel stratum     slurry shield     synchronous grouting     construction technology    

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+, and regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activation and also promotes dendritic cells to mature to enhance their cytokine production. Therefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interest. However, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy. Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation, induced optimal T cell activation without impairing dendritic cell function. In addition, BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity. In the MC38 syngeneic model established in humanized OX40 knock-in mice, BGB-A445 demonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibody showed antitumor efficacy characterized by a hook effect. Furthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody. Taken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast to clinical-stage anti-OX40 antibodies, shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation.

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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Experimental study on pile-end post-grouting piles for super-large bridge pile foundations

Weiming GONG, Guoliang DAI, Haowen ZHANG

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 2,   Pages 228-233 doi: 10.1007/s11709-009-0019-0

Abstract: The application of pile-end post-grouting piles for super-large bridge pile foundations in some importantdiameter varies from 2.5 m to 3 m, and the maximum length is 125 m; the bearing capacity of the post-groutingThe results show that the bearing capacity of the piles are increased in different degrees after grouting, duration of grouting lasting time, are different.In addition, the calculation formula for the post-grouting piles under specified grouting condition was

Keywords： self-balanced testing technique     pile-end post-grouting     bearing capacity     grouting technology    

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Seismic performance of fabricated continuous girder bridge with grouting sleeve-prestressed tendon composite

Frontiers of Structural and Civil Engineering   Pages 827-854 doi: 10.1007/s11709-023-0954-1

Abstract: In this study, a fiber element model of a fabricated concrete pier with grouting sleeve-prestressed tendonsleeve-fabricated pier, and a grouting sleeve-prestressed tendon composite fabricated pier.Under traditional non-near-fault ground motions, the pier top displacements of the grouting sleeve-fabricatedIn addition, the plastic hinge zones of the grouting sleeve-fabricated pier and the composite fabricatedpier shifted to the joint seam and upper edge of the grouting sleeve, respectively.

Keywords： seismic performance     continuous girder bridge     grouting sleeve-prestressed tendon composite connections    

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Treatment techniques for Karst disaster of Maluqing Tunnel on Yichang-Wanzhou Railway

Yang Bing,Xiao Gangzhi

Strategic Study of CAE 2009, Volume 11, Issue 12,   Pages 69-76

Abstract: The feature of karst water burst in Maluqing Tunnel is analyzed first, and then advanced geological forecastingtechnology, hydrological observation, reverse slope drainage technology and water release technologyFinally, curtain grouting technology for stratum consolidation and pile-cap technology for spanning karsttreatment in Maluqing Tunnel will provide a reference to the treatment for karst cave with large quantity water

Keywords： tunnel     Karst water burst     advanced geological forecast     curtain grouting    

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Study on the grouting technology adopted in F1 weathered trough for Xiamen Xiang’an Subsea Tunnel

Guo Xiaohong,Wang Mengshu

Strategic Study of CAE 2011, Volume 13, Issue 9,   Pages 38-41

Abstract:

Focusing on F1 weathered trough which has maximum water inflow and greatdifficulty in construction in Xiamen Xiang'an Subsea Tunnel,full-sectional grouting reinforcementcement single-fluid grouting as major grouting material were applied according to poor geological conditionsand the character of sudden water inflow.Meanwhile,the corresponding parameters of grouting were established after drillings for grouting were

Keywords： Ximen Xiang’an Subsea Tunnel     grouting reinforcement     stability     numerical simulation    

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Clearance grouting process test of Three Gorges Project ship lift rack and nut column

Zhan Jianxia and Li Jihu

Strategic Study of CAE 2013, Volume 15, Issue 9,   Pages 45-49

Abstract:

In order to choose the suitable grouting material and grouting process, and simulate the actual situation of clearance grouting of rack and nut column in ship lift, groutingComparing three kinds of domestic grouting material and the German PAGEL grouting material in groutingIn prototype grouting test, selection of the grouting equipment type, mixing time, templates seal, methodof grouting parameters control of grouting flow were researched, and some applicable grouting material

Keywords： rack     nut column     grouting     ship lift     Three Gorges Project    

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Quantitatively assessing the pre-grouting effect on the stability of tunnels excavated in fault

Xiao YAN, Zizheng SUN, Shucai LI, Rentai LIU, Qingsong ZHANG, Yiming ZHANG

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 6,   Pages 1393-1404 doi: 10.1007/s11709-019-0563-1

Abstract: Pre-grouting is a popular ground treatment strategy utilized to enhance the strength and stability ofFirst, how should the grouting size be determined?Second, when should excavation begin after grouting?tunnel section are evaluated, thereby assisting designers by quantitatively assessing the effects of pre-grouting

Keywords： pre-grouting     stability analysis     factor of safety     discontinuity layout optimization    

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Grouting construction technology of high pressure and rich water fault F11 in Qiyueshan Tunnel

Zhuo Yue,Sun Guoqing

Strategic Study of CAE 2009, Volume 11, Issue 12,   Pages 82-86

Abstract: Water gushing happens in these strata frequently, which affects construction schedule and constructionYichang-Wanzhou Railway crosses underground rivers, karst caves and fractured faults in high pressure and waterFractured fault F11, which has high water pressure, large volume of water gushing and complicated geologicalTaking the technologies of grouting, water control and rock collapse prevention adopted for fault F11control and rock collapse prevention in high pressure and rich water fault F11.

Keywords： Qiyueshan Tunnel     fractured fault     technical challenges     new construction scheme     new construction technology     effect examination method    

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Strengthen the concept of scientific development

Fu Zhihuan

Strategic Study of CAE 2012, Volume 14, Issue 3,   Pages 15-20

Abstract:

This article introduces the development progress and evolution tends of international transportation since the hundred odd years. Then related with the situation of domestic practice, on one hand, we should affirm our great achievements in the domain of transportation; on the other hand, we also indicate the problems existing at present. This article points out that in order to solve these problems, we must fulfil the scientific development concepts seriously, develop the integrated transportation system unflinchingly and prevent impulse in the construction of infrastructure blindly. At the same time, the author gives some political suggestions for development of integrated transportation system, including optimize the structure of transportation network, pay attention to the planning of transport pivot, enhance the construction level of integrated transport information, advance the system reform of transportation management, establish a unitary management organization for transportation profession, strengthening the legal system, formulating the complete policy and so on.

Keywords： transportation     integrated transport    

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Thoughts on strengthen the railway construction for coal transportation in China

Song Caiping

Strategic Study of CAE 2009, Volume 11, Issue 9,   Pages 78-80

Abstract:

The coal resources in China are mainly distributed in northwest parts, especially in Shanxi Province, north part of Shanxi Province and west part of Inner Mongolia, while the areas which consume coals most are the north and central south parts, thus the pattern of transporting coals in north to south and transporting coals in west to east comes into being. Coal transportation has been being the key point of railway transportation for a long time. Strengthening the railway construction for coal transportation to ensure safe and steady coal supply is significant to the safety of national energy strategy.

Keywords： railway     coal     transportation construction    

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Analysis for the Stability of Covered Karst Base and a Pre-disposing Way with Pressure Grouting

Sun Chengfang,Yang Anrong,Dong Hanxiong,Peng Shaomin

Strategic Study of CAE 2002, Volume 4, Issue 7,   Pages 56-59

Abstract: karst base, a kind of way, which can be adopted to predispose the covered karst base using pressure groutingThe evaluation of grouting effect indicates this way can be carried out economically and technically.

Keywords： karst base     pressure grouting     evaluation of effect    

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Treatment of Highly Weathered Rock Mass at the Abutment of Earth-Rock Dam in Qiaoqi Hydropower Project

Wang Shougen

Strategic Study of CAE 2005, Volume 7, Issue 3,   Pages 78-83

Abstract: The treatment scheme for the highly weathering rock mass on both abutments and grouting tests and groutingThe feasibility to adopt consolidation grouting and seepage treatment measures is argued and the treatment

Keywords： Qiaoqi Hydropower Station     earth-rock dam     treatment of abutment     highly weathered rock mass     consolidation grouting     curtain grouting    

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Title Author Date Type Operation

Design new ideas and engineering practice of high-pressure water-rich fault “outside block and insidestrenghthen grouting”

Zhang Minqing,Zhang Mei

Journal Article

Synchronous grouting of large diameter slurry shield in water-rich sandy gravel stratum

Zhang Changqiang,Zhai Zhiguo,Chen Mingjuan,Jin Zhongxiang

Journal Article

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article

Experimental study on pile-end post-grouting piles for super-large bridge pile foundations

Weiming GONG, Guoliang DAI, Haowen ZHANG

Journal Article

Seismic performance of fabricated continuous girder bridge with grouting sleeve-prestressed tendon composite

Journal Article

Treatment techniques for Karst disaster of Maluqing Tunnel on Yichang-Wanzhou Railway

Yang Bing,Xiao Gangzhi

Journal Article

Study on the grouting technology adopted in F1 weathered trough for Xiamen Xiang’an Subsea Tunnel

Guo Xiaohong,Wang Mengshu

Journal Article

Clearance grouting process test of Three Gorges Project ship lift rack and nut column

Zhan Jianxia and Li Jihu

Journal Article

Quantitatively assessing the pre-grouting effect on the stability of tunnels excavated in fault

Xiao YAN, Zizheng SUN, Shucai LI, Rentai LIU, Qingsong ZHANG, Yiming ZHANG

Journal Article

Beijing Nonferrous Metals Research Institute to Strengthen Technological Innovation and Create a Sustainable

Journal Article

Grouting construction technology of high pressure and rich water fault F11 in Qiyueshan Tunnel

Zhuo Yue,Sun Guoqing

Journal Article

Strengthen the concept of scientific development

Fu Zhihuan

Journal Article

Thoughts on strengthen the railway construction for coal transportation in China

Song Caiping

Journal Article

Analysis for the Stability of Covered Karst Base and a Pre-disposing Way with Pressure Grouting

Sun Chengfang,Yang Anrong,Dong Hanxiong,Peng Shaomin

Journal Article

Treatment of Highly Weathered Rock Mass at the Abutment of Earth-Rock Dam in Qiaoqi Hydropower Project

Wang Shougen

Journal Article